-
DE
D53.1 – Other Megaloblastic Anaemias
D53.1 is the ICD-10 code for other megaloblastic anaemias, caused by impaired DNA synthesis in red blood cells and not solely explained by vitamin B12 or folate deficiency.
Add as Preferred SourceThings worth knowing about "D53.1"
D53.1 is the ICD-10 code for other megaloblastic anaemias, caused by impaired DNA synthesis in red blood cells and not solely explained by vitamin B12 or folate deficiency.
What Does D53.1 Mean?
The ICD-10 diagnosis code D53.1 stands for Other megaloblastic anaemias, not elsewhere classified (NEC). This code is used when a megaloblastic anaemia is present that cannot be clearly attributed to vitamin B12 deficiency (D51) or folate deficiency (D52), or when the exact underlying cause has not yet been determined. Megaloblastic anaemia is a blood disorder in which red blood cells (erythrocytes) are abnormally enlarged and immature due to impaired DNA synthesis.
Causes
D53.1 includes megaloblastic anaemias triggered by various causes:
- Drug-induced: Certain medications such as methotrexate, hydroxyurea, trimethoprim, or antiretroviral drugs can inhibit DNA synthesis and cause megaloblastic anaemia.
- Inborn errors of metabolism: Rare genetic conditions affecting folate or vitamin B12 metabolism (e.g., methylmalonic acidemia, homocystinuria).
- Hereditary orotic aciduria: A rare inherited disorder of pyrimidine synthesis leading to megaloblastic changes without any vitamin deficiency.
- Thiamine deficiency (vitamin B1): In rare cases, thiamine deficiency can also lead to megaloblastic anaemia (thiamine-responsive megaloblastic anaemia, TRMA).
- Unknown cause: In some cases, no clear cause can be identified.
Symptoms
The symptoms of megaloblastic anaemia coded as D53.1 are similar to those of other anaemias but may include additional features:
- Fatigue, weakness, and general malaise
- Pale or slightly yellowish skin (jaundice)
- Shortness of breath and reduced exercise tolerance
- Heart palpitations
- Dizziness and headaches
- Tongue and oral mucosal inflammation (glossitis, stomatitis)
- Neurological symptoms (depending on the underlying cause)
Diagnosis
The diagnosis of megaloblastic anaemia and assignment to the code D53.1 is established through:
- Full blood count: Detection of enlarged red blood cells (macrocytosis, elevated MCV) and abnormal white blood cells (hypersegmented neutrophils).
- Serum levels: Measurement of vitamin B12, folate, homocysteine, and methylmalonic acid to rule out classic deficiency states.
- Bone marrow examination: Identification of typical megaloblastic changes (enlarged, immature precursor cells).
- Genetic testing: When an inborn error of metabolism is suspected.
- Medication history: A thorough review of all medications taken that may affect DNA synthesis.
Treatment
Treatment depends on the underlying cause:
- Drug-induced cause: Discontinuation or substitution of the causative medication; if necessary, folinic acid supplementation (leucovorin) as an antidote in methotrexate therapy.
- Inborn errors of metabolism: Specific therapy depending on the condition, e.g., uridine supplementation for orotic aciduria, thiamine for TRMA.
- Supportive therapy: In cases of severe anaemia, blood transfusion may be required.
- Nutrient substitution: If secondary nutrient deficiencies are present, these are corrected accordingly.
References
- World Health Organization (WHO): ICD-10 Version 2019, Chapter III, D53.1 – Other megaloblastic anaemias, not elsewhere classified.
- Hoffbrand AV, Pettit JE, Moss PAH: Essential Haematology, 7th edition, Wiley-Blackwell, 2016.
- Green R et al.: Megaloblastic anemias: nutritional and other causes. Medical Clinics of North America, 2017; 101(2): 297–317. PMID: 28189172.
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Skip product gallery
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
22,90 €
Discount
Subscription available
Lactoferrin 60 Capsules
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
60 Capsules
Sale price:
50,00 €
Regular price:
59,90 €
Subscription available
Multivitamin Mineral Complex
Daily basic supply: the complete spectrum of micronutrients
Natural multivitamin complex for the immune system, energy, and central body functions
30 Capsules
Regular price:
29,90 €
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
35,90 €