-
DE
D64.3 – Sideroblastic Anaemia: Causes & Treatment
D64.3 is the ICD-10 code for other sideroblastic anaemias, where iron accumulates abnormally in bone marrow red cell precursors, impairing haemoglobin production and causing anaemia.
Add as Preferred SourceThings worth knowing about "D64.3"
D64.3 is the ICD-10 code for other sideroblastic anaemias, where iron accumulates abnormally in bone marrow red cell precursors, impairing haemoglobin production and causing anaemia.
What is D64.3?
The ICD-10 code D64.3 refers to other sideroblastic anaemias – a group of blood disorders in which the bone marrow is unable to properly incorporate iron into haemoglobin, the oxygen-carrying protein in red blood cells. Instead, iron accumulates in the mitochondria of developing red blood cell precursors (erythroblasts), forming characteristic ring-shaped deposits known as ring sideroblasts. This code is used when the condition cannot be attributed to drug use or other clearly defined causes covered by separate ICD-10 codes.
Causes
Sideroblastic anaemias classified under D64.3 can arise from several different causes:
- Hereditary forms: Mutations in genes involved in haem synthesis or iron metabolism, such as ALAS2 or SLC25A38.
- Idiopathic acquired forms: No identifiable external cause; often associated with myelodysplastic syndromes (MDS).
- Metabolic disorders: For example, copper deficiency, which impairs enzymes involved in iron utilisation.
- Mitochondrial diseases: Rare defects in mitochondrial function that disrupt haem synthesis.
- Other systemic conditions: Inflammatory or systemic diseases that affect iron metabolism.
Symptoms
The symptoms are typical of anaemia and may vary in severity:
- Fatigue, weakness, and general malaise
- Pale skin and mucous membranes
- Shortness of breath during physical activity
- Heart palpitations
- Dizziness and headaches
- In chronic cases: signs of iron overload (haemosiderosis), such as liver disease, heart problems, or diabetes
Diagnosis
The diagnosis of sideroblastic anaemia (D64.3) is based on a combination of investigations:
- Full blood count: Typically reveals a hypochromic (pale) and microcytic (small cell) or normocytic anaemia.
- Iron studies: Elevated serum iron, high transferrin saturation, and normal or raised ferritin levels.
- Bone marrow biopsy: Detection of ring sideroblasts (more than 15% of erythroblasts) using Prussian blue staining – the key diagnostic criterion.
- Genetic testing: To identify hereditary forms.
- Exclusion of other causes: Such as medications, alcohol use, or vitamin B6 deficiency.
Treatment
Treatment depends on the underlying cause:
- Vitamin B6 (pyridoxine): High-dose pyridoxine supplementation may be effective in certain hereditary forms (e.g. ALAS2 mutations).
- Treatment of the underlying condition: For example, copper supplementation in copper deficiency.
- Blood transfusions: For symptomatic relief in severe anaemia.
- Iron chelation therapy: In cases of iron overload, chelating agents such as deferoxamine are used to remove excess iron from the body.
- Stem cell transplantation: May be considered in severe or refractory cases.
References
- World Health Organization (WHO): ICD-10 International Classification of Diseases, 10th Revision – D64.3 Other sideroblastic anaemias.
- Bottomley, S. S. & Fleming, M. D. (2014): Sideroblastic anaemia: diagnosis and management. British Journal of Haematology, 164(6), 818–830.
- Steensma, D. P. (2011): The changing classification of sideroblastic disorders. Hematology, American Society of Hematology Education Program, 2011, 116–120.
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Skip product gallery
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
22,90 €
Discount
Subscription available
Lactoferrin 60 Capsules
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
60 Capsules
Sale price:
50,00 €
Regular price:
59,90 €
Subscription available
Multivitamin Mineral Complex
Daily basic supply: the complete spectrum of micronutrients
Natural multivitamin complex for the immune system, energy, and central body functions
30 Capsules
Regular price:
29,90 €
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
35,90 €