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K52.8 – Non-infective Gastroenteritis & Colitis

K52.8 is an ICD-10 diagnosis code for other specified non-infective gastroenteritis and colitis. It describes inflammation of the gastrointestinal tract without an infectious cause.

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Things worth knowing about "K52.8"

K52.8 is an ICD-10 diagnosis code for other specified non-infective gastroenteritis and colitis. It describes inflammation of the gastrointestinal tract without an infectious cause.

What does the diagnosis code K52.8 mean?

The ICD-10 code K52.8 stands for other specified non-infective gastroenteritis and colitis. It belongs to the group of non-infective inflammations of the gastrointestinal tract and is used when inflammation of the stomach, small intestine, or colon is present that is not caused by bacteria, viruses, or other pathogens, and that can be assigned to a more specific sub-diagnosis.

Causes

The conditions classified under K52.8 can have various non-infective causes:

Food intolerances (e.g., lactose intolerance, gluten intolerance)
Allergic reactions to certain foods or substances
Drug-induced colitis, triggered by antibiotics, NSAIDs, or other medications
Radiation colitis following radiotherapy in the abdominal area
Microscopic colitis (collagenous or lymphocytic colitis)
Eosinophilic gastroenteritis, a rare condition with excessive infiltration of eosinophilic granulocytes into the intestinal wall
Chemical or toxic influences

Symptoms

The symptoms of non-infective gastroenteritis or colitis can vary depending on the cause and the affected section of the intestine. Common complaints include:

Diarrhea, sometimes chronic or recurring
Abdominal pain and cramps
Blood or mucus in the stool (depending on the cause)
Nausea and vomiting
Bloating and flatulence
General malaise and fatigue

Diagnosis

Diagnosis is made through a combination of:

Medical history: dietary habits, medication use, pre-existing conditions
Laboratory tests: blood count, inflammatory markers (CRP, ESR), stool analysis
Colonoscopy with biopsy for histological examination
Imaging procedures such as ultrasound or MRI if needed
Exclusion of infectious causes through pathogen detection in stool

Treatment

Treatment is tailored to the underlying cause:

Dietary adjustments: avoidance of triggers such as lactose, gluten, or specific foods
Discontinuation or change of medications that triggered the colitis
Drug therapy: corticosteroids, mesalazine, or budesonide for inflammatory forms
Probiotics to support intestinal flora
Symptomatic treatment: antispasmodics for cramping, electrolyte replacement for diarrhea

Clinical Relevance

The ICD-10 code K52.8 is clinically significant as it covers a broad group of intestinal diseases not caused by infections. Accurate diagnosis is essential to initiate the correct therapy and to prevent chronic progression. Persistent or severe symptoms should always be assessed by a specialist.

References

World Health Organization (WHO): International Classification of Diseases, 10th Revision (ICD-10). Chapter XI: Diseases of the Digestive System (K00–K93). Geneva: WHO.
Fernández-Bañares F. et al.: Microscopic Colitis: A Review. Digestive Diseases and Sciences, 2022.
Lacy B.E. et al.: ACG Clinical Guideline: Management of Irritable Bowel Syndrome. American Journal of Gastroenterology, 2021.

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