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Splenic Function Test – Diagnosis & Significance

A splenic function test is a diagnostic procedure used to assess how well the spleen is working. It helps detect conditions such as hyposplenia or asplenia at an early stage.

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Things worth knowing about "Splenic Function Test"

A splenic function test is a diagnostic procedure used to assess how well the spleen is working. It helps detect conditions such as hyposplenia or asplenia at an early stage.

What is a Splenic Function Test?

A splenic function test refers to a group of diagnostic procedures used to evaluate how well the spleen is performing its essential tasks. The spleen is a vital organ involved in both the immune system and blood cell regulation. It filters the blood, removes old or damaged red blood cells, and plays a key role in defending the body against certain pathogens -- particularly encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis.

Splenic function testing is indicated when there is concern that the spleen is not functioning properly. This may occur following surgical removal of the spleen (splenectomy), in the presence of certain blood disorders, or in cases of congenital immune deficiencies.

When is a Splenic Function Test Performed?

This test is particularly relevant in the following clinical situations:

After splenectomy (surgical removal of the spleen), for example following trauma or treatment of conditions such as Hodgkin lymphoma
When hyposplenia (reduced splenic function) is suspected, such as in sickle cell disease, coeliac disease, or systemic lupus erythematosus
In cases of asplenia (congenital or acquired absence of the spleen)
For monitoring patients with haematological conditions such as thalassaemia
In patients with recurrent severe infections caused by encapsulated bacteria

Methods of Splenic Function Testing

Blood Smear and Detection of Howell-Jolly Bodies

The most commonly used method is the microscopic examination of a peripheral blood smear. This involves looking for Howell-Jolly bodies -- small remnants of nuclear material found within red blood cells that are normally filtered out by a healthy spleen. The presence of these inclusions in the bloodstream indicates impaired or absent splenic function.

Splenic Scintigraphy

In splenic scintigraphy, red blood cells labelled with a mildly radioactive substance are injected into the bloodstream. A gamma camera then measures the extent to which the spleen takes up and processes these labelled cells. This method provides information about both the function and the size and position of the spleen.

Pitted Red Cell Count

Another method involves counting pitted red cells -- erythrocytes that contain surface membrane pits or vacuoles. Using an interference-phase contrast microscope, the proportion of these altered red blood cells in the circulation is measured. An elevated count is a sensitive indicator of reduced splenic filtration capacity and is considered one of the most reliable tests for assessing splenic function.

Imaging Procedures

Complementary imaging methods such as ultrasound (sonography), computed tomography (CT), or magnetic resonance imaging (MRI) can be used to visualise the size, location, and structural changes of the spleen. However, these methods do not replace functional assessments.

What Do the Test Results Indicate?

An abnormal splenic function test may point to one of the following conditions:

Asplenia: complete absence of splenic function, often following splenectomy or present from birth
Hyposplenia: reduced but still present splenic function
Hypersplenism: excessively increased splenic activity leading to accelerated destruction of blood cells

Patients with asplenia or severe hyposplenia face a significantly elevated risk of severe, life-threatening infections -- particularly from encapsulated bacteria. These are referred to as OPSI (Overwhelming Post-Splenectomy Infection) and require specific preventive measures.

Consequences and Management

If reduced splenic function is identified, the following measures are typically recommended:

Vaccinations against pneumococci, meningococci, and Haemophilus influenzae type b
Antibiotic prophylaxis, especially in children and high-risk patients
Patient education about warning signs of severe infection and the importance of seeking immediate medical attention in the event of fever
Regular follow-up examinations to monitor splenic function over time

References

Davies JM et al. - Review of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Clinical Medicine, 2011; 11(3): 253-256. PubMed PMID: 21725130.
William H. Crosby - The Normal and Pathologic Physiology of the Spleen. In: Williams Hematology, 9th Edition, McGraw-Hill Education, 2016.
World Health Organization (WHO) - Immunization in Special Circumstances: Asplenia and Hyposplenia. WHO Guidelines, Geneva, 2020. Available at: https://www.who.int

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