-
DE
Perenterol – Effects, Dosage and Uses
Perenterol is a medicinal product containing the probiotic yeast Saccharomyces boulardii, used to treat and prevent diarrhea and support gut flora balance.
Add as Preferred SourceThings worth knowing about "Perenterol"
Perenterol is a medicinal product containing the probiotic yeast Saccharomyces boulardii, used to treat and prevent diarrhea and support gut flora balance.
What is Perenterol?
Perenterol is a pharmacy-only medicinal product containing the probiotic yeast Saccharomyces boulardii as its active ingredient. It is used for the prevention and treatment of diarrheal diseases. Perenterol is available in various forms including capsules, powder, and sachets, and is suitable for both adults and children (e.g., Perenterol junior).
Mechanism of Action
Saccharomyces boulardii is a naturally occurring, non-pathogenic yeast that does not belong to the normal gut flora and is completely eliminated from the intestine after the treatment is stopped. It works through several mechanisms:
- Inhibition of pathogens: Saccharomyces boulardii produces proteases (enzymes) that break down toxins from diarrhea-causing organisms such as Clostridium difficile and enterotoxigenic Escherichia coli.
- Strengthening the intestinal barrier: The yeast stimulates the production of secretory immunoglobulin A (sIgA), thereby reinforcing the protective function of the intestinal mucosa.
- Regulation of gut flora: It supports the balance of the natural gut microbiome, particularly after antibiotic therapy.
- Anti-inflammatory effects: Saccharomyces boulardii can reduce inflammatory processes in the gut and enhance local immune defenses.
Indications
Perenterol is indicated for the following conditions:
- Acute infectious diarrhea (e.g., traveler's diarrhea)
- Antibiotic-associated diarrhea (diarrhea as a side effect of antibiotic treatment)
- Prevention of traveler's diarrhea
- Inflammatory bowel disease (as a supportive measure)
- Diarrhea in infants and children (Perenterol junior)
Dosage and Administration
The exact dosage of Perenterol depends on the age, body weight, and severity of the condition. General guidelines include:
- Adults: Typically 1-2 capsules or sachets (250 mg each) once or twice daily.
- Children (Perenterol junior): Dosed according to body weight, usually 1 sachet (250 mg) once or twice daily.
- Should be taken with sufficient liquid. The powder can be stirred into lukewarm water or juice.
- For acute diarrhea, the recommended duration of treatment is generally 5-10 days.
Side Effects
Perenterol is generally well tolerated. Known side effects include:
- Common: Flatulence, bloating, mild abdominal discomfort at the start of treatment
- Rare: Allergic reactions to yeast components (especially in individuals with known yeast allergy)
- Very rare: Fungemia (entry of yeast into the bloodstream) in severely immunocompromised patients
Contraindications and Warnings
Perenterol should not be used in:
- Patients with known allergy to Saccharomyces boulardii or other yeasts
- Severely immunocompromised patients (e.g., HIV/AIDS, chemotherapy, organ transplant recipients) -- medical advice should be sought before use
- Patients with central venous catheters (increased risk of fungemia)
During pregnancy and breastfeeding, Perenterol should only be used after consulting a healthcare professional.
References
- McFarland LV. -- Saccharomyces boulardii in the Prevention and Treatment of Antibiotic-Associated Diarrhoea -- Alimentary Pharmacology and Therapeutics (2010)
- World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics -- World Gastroenterology Organisation (WGO), 2023. https://www.worldgastroenterology.org
- Perenterol Summary of Product Characteristics -- Biocodex GmbH, current version. https://www.fachinfo.de
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Skip product gallery
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
22,90 €
Discount
Subscription available
Lactoferrin 60 Capsules
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
60 Capsules
Sale price:
50,00 €
Regular price:
59,90 €
Discount
Subscription available
Multivitamin Mineral Complex
Daily basic supply: the complete spectrum of micronutrients
Natural multivitamin complex for the immune system, energy, and central body functions
30 Capsules
Sale price:
27,90 €
Regular price:
29,90 €
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
35,90 €
Most read entries
3 Posts in this encyclopedia categoryMagnesiumcarbonat
Magnesiumcarbonat ist eine anorganische Magnesiumverbindung mit säure-neutralisierender (antazidischer) Wirkung. Erfahre mehr über Vorteile, Einsatzgebiete und Unterschiede zu besser resorbierbaren Magnesiumformen.
Calorie content
The choice of food influences our energy intake. The calorie content varies greatly - some provide little energy, others a lot.
Cologne list
The Cologne List ® is an important initiative in competitive sports that offers athletes guidance in the selection of nutritional supplements.