-
DE
Vitamin E Deficiency: Causes, Symptoms and Treatment
Vitamin E deficiency refers to abnormally low levels of the fat-soluble vitamin E in the body. It can cause neurological problems, muscle weakness, and a weakened immune system.
Add as Preferred SourceThings worth knowing about "Vitamin E Deficiency"
Vitamin E deficiency refers to abnormally low levels of the fat-soluble vitamin E in the body. It can cause neurological problems, muscle weakness, and a weakened immune system.
What is Vitamin E Deficiency?
Vitamin E is a fat-soluble vitamin that acts as a key antioxidant in the human body. It protects cells from oxidative damage, supports immune function, and plays a role in neurological and muscular cell signalling. Vitamin E deficiency occurs when blood levels of the vitamin fall below the normal reference range – generally below 12 µmol/l for alpha-tocopherol, the most biologically active form of the vitamin.
Causes
Vitamin E deficiency is uncommon in healthy adults with a balanced diet in developed countries. It more frequently arises as a consequence of underlying conditions or specific circumstances:
- Fat malabsorption: Because vitamin E is fat-soluble, conditions such as Crohn's disease, coeliac disease, short bowel syndrome, or cystic fibrosis can significantly impair its absorption in the intestine.
- Liver disease: The liver is involved in processing and transporting vitamin E. Severe liver disease can therefore contribute to deficiency.
- Genetic disorders: Rare conditions such as ataxia with vitamin E deficiency (AVED) impair the normal transport of vitamin E throughout the body.
- Premature birth: Premature infants have limited vitamin E stores and are at particularly high risk.
- Very low-fat diets: Extremely fat-restricted diets over a long period can reduce the absorption of vitamin E.
Symptoms
The symptoms of vitamin E deficiency develop gradually and primarily affect the nervous and muscular systems:
- Peripheral neuropathy: Tingling, numbness, or pain in the hands and feet due to nerve fibre damage
- Ataxia: Loss of balance and coordination, unsteady gait
- Muscle weakness (myopathy): Reduced muscle strength and muscle wasting
- Visual disturbances: Deterioration of vision due to damage to the retina (retinopathy)
- Weakened immune system: Increased susceptibility to infections
- Haemolysis: Premature breakdown of red blood cells, especially in newborns
Diagnosis
Vitamin E deficiency is primarily diagnosed through a blood test measuring serum alpha-tocopherol levels. Since vitamin E is transported bound to lipoproteins, results should ideally be interpreted relative to total lipids or cholesterol levels. Additional neurological examinations and, where appropriate, genetic testing for AVED may also be performed.
Treatment
Dietary Adjustment
For mild deficiency, targeted dietary changes can be beneficial. Good dietary sources of vitamin E include:
- Vegetable oils (wheat germ oil, sunflower oil, rapeseed oil)
- Nuts and seeds (almonds, hazelnuts, sunflower seeds)
- Green leafy vegetables (spinach, Swiss chard)
- Avocado and red pepper
Supplementation
In cases of more severe deficiency or when malabsorption is present, vitamin E supplementation is necessary. The dosage depends on the severity of the deficiency and any underlying condition. In AVED, very high doses under medical supervision may be required. The World Health Organization (WHO) and the European Food Safety Authority (EFSA) set the tolerable upper intake level for adults at 300 mg per day. Standard recommended daily intakes for adults range from approximately 11–15 mg of alpha-tocopherol equivalents.
Treatment of the Underlying Condition
Because vitamin E deficiency is often a consequence of another illness, treating the underlying cause is essential for achieving lasting improvement.
Risk Groups
Individuals at particular risk of vitamin E deficiency include:
- People with chronic bowel conditions or fat malabsorption
- Premature infants and newborns
- Individuals with rare genetic disorders of lipoprotein metabolism
- Patients with severe liver disease
- People following very one-sided, extremely low-fat diets
References
- Traber MG. Vitamin E deficiency in humans: Causes and consequences. Free Radical Biology and Medicine. 2014;84:357-366. doi:10.1016/j.freeradbiomed.2015.04.006
- World Health Organization (WHO): Vitamin and Mineral Requirements in Human Nutrition. 2nd edition. Geneva: WHO Press, 2004.
- European Food Safety Authority (EFSA): Dietary Reference Values for Vitamin E as alpha-tocopherol. EFSA Journal. 2015;13(7):4149. doi:10.2903/j.efsa.2015.4149
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Skip product gallery
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
22,90 €
Discount
Subscription available
Lactoferrin 60 Capsules
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
60 Capsules
Sale price:
50,00 €
Regular price:
59,90 €
Discount
Subscription available
Multivitamin Mineral Complex
Daily basic supply: the complete spectrum of micronutrients
Natural multivitamin complex for the immune system, energy, and central body functions
30 Capsules
Sale price:
27,90 €
Regular price:
29,90 €
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
35,90 €
Most read entries
3 Posts in this encyclopedia categoryMagnesiumcarbonat
Magnesiumcarbonat ist eine anorganische Magnesiumverbindung mit säure-neutralisierender (antazidischer) Wirkung. Erfahre mehr über Vorteile, Einsatzgebiete und Unterschiede zu besser resorbierbaren Magnesiumformen.
Calorie content
The choice of food influences our energy intake. The calorie content varies greatly - some provide little energy, others a lot.
Cologne list
The Cologne List ® is an important initiative in competitive sports that offers athletes guidance in the selection of nutritional supplements.