Spermidine (EN: spermidine), a naturally occurring polyamine, has established itself as a key active ingredient in anti-ageing and health research. Scientists worldwide, including Dr. David Sinclair, Professor of Genetics at Harvard Medical School and a leading expert in aging research/biohackers, are increasingly describing the role of spermidine in activating life-prolonging processes such as autophagy in their studies. The work of Dr. Sinclair and other researchers focusing on the mechanisms of healthy aging has increasingly identified spermidine as a compound of high interest around autophagy, cell health and aging processes.
What is autophagy – cellular self-cleaning?
A central process that spermidine supports is autophagy. This natural cleaning mechanism in our cells ensures that damaged or superfluous cell components are broken down and recycled. During autophagy, damaged cell components are enclosed in so-called autophagosomes, which then fuse with lysosomes. There, the components are broken down and recycled, which not only maintains cell health, but also slows down ageing processes and minimizes cell damage. Dr. David Sinclair emphasizes that the promotion of autophagy is crucial for extending lifespan and preventing disease. Spermidine acts as a natural enhancer of this process.
Spermidine and anti-ageing – stay young and healthy for longer
Research has also shown that a spermidine-rich diet is associated with an extended lifespan and improved cell function. The main effect of spermidine is based on the aforementioned activation of autophagy.
Spermidine is currently thought to improve mitochondrial function, reduce inflammation and increase cell resistance to oxidative stress. These effects help to slow down the ageing process and prevent age-related diseases, including dementia. In particular, spermidine is said to have a neuroprotective effect, as it can inhibit the accumulation of harmful proteins in brain cells.
Sources and supplementation of spermidine
Spermidine occurs naturally in foods such as wheat germ, soybeans, ripened cheese and mushrooms. Wheat germ extract in particular is a popular source as it is especially rich in spermidine. Food supplements with spermidine are becoming increasingly important, especially for people who want to support their cellular health and prevent signs of ageing.
The spermidine complex CELVIO® was selected for artgerecht because it not only meets the highest quality standards,Sources
- Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374), eaan2788.
- Gupta, V. K., Scheunemann, L., Eisenberg, T., et al. (2013). Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nature Neuroscience, 16(10), 1453-1460.
- Minois, N. (2014). Molecular basis of the anti-aging effect of spermidine and other natural polyamines – a mini-review. Gerontology, 60(4), 319-26.
- Schwarz, C., Stakovic, S., et al. (2018) Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging, 10(1) 19-33.
- Sinclair, D. A., & LaPlante, M. D. (2019). Lifespan: Why We Age – and Why We Don’t Have To. Atria Books.
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