-
DE
Artemisinin Combination Therapy (ACT) | Malaria
Artemisinin combination therapy (ACT) is the WHO-recommended standard treatment for malaria. It combines fast-acting artemisinin compounds with a longer-lasting partner drug for maximum efficacy.
Add as Preferred SourceThings worth knowing about "Artemisinin combination therapy"
Artemisinin combination therapy (ACT) is the WHO-recommended standard treatment for malaria. It combines fast-acting artemisinin compounds with a longer-lasting partner drug for maximum efficacy.
What Is Artemisinin Combination Therapy?
Artemisinin combination therapy (ACT) is the first-line treatment for uncomplicated malaria recommended by the World Health Organization (WHO), particularly for infections caused by Plasmodium falciparum. ACT pairs a rapidly acting artemisinin-derived compound with a second antimalarial drug that has a longer half-life. This combination approach maximizes treatment effectiveness and significantly reduces the risk of the malaria parasite developing resistance to either drug.
Mechanism of Action
Artemisinin and its derivatives – including artemether, artesunate, and dihydroartemisinin – act rapidly against the blood-stage malaria parasite. They generate reactive oxygen species (free radicals) that are toxic to the parasite, causing widespread cellular damage. Because artemisinin derivatives are eliminated from the body quickly, a slower-acting partner drug is always combined to clear any remaining parasites and prevent recrudescence (return of the infection).
Common Drug Combinations
- Artemether + Lumefantrine (e.g., Coartem®) – the most widely used ACT combination globally
- Artesunate + Amodiaquine – widely used across sub-Saharan Africa
- Artesunate + Mefloquine – commonly used in Southeast Asia
- Dihydroartemisinin + Piperaquine – effective with a favorable tolerability profile
- Artesunate + Pyronaridine – a newer combination with strong clinical evidence
Usage and Dosage
ACT is typically administered orally over a three-day course. Dosing is weight-based, which is especially important when treating children. For severe malaria, intravenous or intramuscular artesunate is the preferred treatment. It is essential to complete the full course of treatment as prescribed in order to prevent the development of drug resistance.
Indications
ACT is primarily indicated for:
- Uncomplicated falciparum malaria (caused by Plasmodium falciparum)
- Malaria caused by other Plasmodium species in certain geographic regions
- Vulnerable populations in endemic areas, including children under five years of age
Side Effects
ACT medications are generally well tolerated. Possible side effects include:
- Nausea, vomiting, and abdominal discomfort
- Dizziness and headache
- Cardiac effects such as QT interval prolongation (depending on the partner drug)
- Skin reactions including itching or rash
- Rarely: elevated liver enzymes
Resistance and Global Challenges
A growing concern is the emergence of artemisinin resistance, first detected in Southeast Asia, particularly in the Greater Mekong Subregion. Resistant parasites show a slowed response to treatment. The WHO closely monitors resistance patterns worldwide and strongly advises against the use of artemisinin monotherapy, which is a major driver of resistance development.
Importance for Global Health
The widespread adoption of ACT has dramatically reduced malaria mortality worldwide. In sub-Saharan Africa, where malaria remains endemic, ACT has saved millions of lives, especially among young children. It remains a cornerstone of the global malaria control and elimination strategy, supported by organizations such as the WHO, UNICEF, and the Global Fund.
References
- World Health Organization (WHO): Guidelines for the Treatment of Malaria, 3rd Edition (2015). Available at: https://www.who.int/publications/i/item/9789241549127
- Ashley E. A. et al.: Spread of Artemisinin Resistance in Plasmodium falciparum Malaria. New England Journal of Medicine, 371(5), 411–423 (2014). DOI: 10.1056/NEJMoa1314981
- Sinclair D. et al.: Artemisinin-based combination therapy for treating uncomplicated malaria. Cochrane Database of Systematic Reviews, Issue 12 (2009). DOI: 10.1002/14651858.CD007483.pub2
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Verwandte Produkte
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
€22.90
Subscription available
Lactoferrin
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.[siehe Varianten]
Regular price:
€59.90
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
€35.90
Most read entries
3 Posts in this encyclopedia categoryMagnesiumcarbonat
Magnesiumcarbonat ist eine anorganische Magnesiumverbindung mit säure-neutralisierender (antazidischer) Wirkung. Erfahre mehr über Vorteile, Einsatzgebiete und Unterschiede zu besser resorbierbaren Magnesiumformen.
Calorie content
The choice of food influences our energy intake. The calorie content varies greatly - some provide little energy, others a lot.
Cologne list
The Cologne List ® is an important initiative in competitive sports that offers athletes guidance in the selection of nutritional supplements.