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Heart Valve Disease: Causes, Symptoms & Treatment

Heart valve disease occurs when one or more of the heart valves do not work properly, affecting blood flow through the heart and potentially causing serious symptoms.

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Things worth knowing about "Heart Valve Disease"

Heart valve disease occurs when one or more of the heart valves do not work properly, affecting blood flow through the heart and potentially causing serious symptoms.

What Is Heart Valve Disease?

The heart has four valves – the mitral valve, the aortic valve, the tricuspid valve, and the pulmonary valve – that regulate blood flow in the correct direction. In heart valve disease, at least one of these valves is not functioning properly. There are two main types of valve dysfunction: stenosis (the valve is narrowed and does not open fully) and regurgitation or insufficiency (the valve does not close properly, allowing blood to flow backward). In some cases, both problems occur in the same valve simultaneously.

Causes

Heart valve disease can be present from birth (congenital) or develop later in life (acquired).

Congenital defects: Structural abnormalities present at birth, such as a bicuspid aortic valve (only two leaflets instead of three).
Rheumatic fever: A complication of streptococcal infection that can cause scarring of the heart valves.
Calcification and degeneration: With age, calcium deposits can cause valves to stiffen and narrow, most commonly affecting the aortic valve.
Heart attack: Damage to the heart muscle can impair the function of nearby valves.
Infective endocarditis: A bacterial infection of the heart valves that can lead to their destruction.
Connective tissue disorders: Conditions such as Marfan syndrome can weaken the valve structures.

Symptoms

Symptoms vary depending on the valve affected and the severity of the dysfunction. Mild cases are often symptom-free. Common symptoms include:

Shortness of breath, especially during physical activity or when lying down
Fatigue and weakness
Heart palpitations or irregular heartbeat (arrhythmia)
Chest pain or tightness
Dizziness or fainting episodes
Swelling (edema) in the legs, ankles, or abdomen
Heart murmur, detected by a physician using a stethoscope

Diagnosis

Heart valve disease is diagnosed through a combination of examinations and tests:

Physical examination: A doctor listens with a stethoscope for heart murmurs that may indicate valve problems.
Echocardiography (cardiac ultrasound): The primary diagnostic tool, providing detailed images of the structure and function of the heart valves.
Electrocardiogram (ECG): Records the electrical activity of the heart to detect rhythm abnormalities.
Chest X-ray: Assesses heart size and any changes in the lungs.
Cardiac catheterization: Used when further details are needed, especially before surgery.
Cardiac MRI: Provides detailed imaging of heart structures as a complementary method.

Treatment

Treatment depends on the type, severity, and associated symptoms of the valve disease.

Medical Management

Medications can relieve symptoms and prevent complications but cannot repair the valve itself. Commonly used medications include:

Blood pressure medications (e.g., ACE inhibitors, beta-blockers) to reduce the workload on the heart
Diuretics to reduce fluid retention and swelling
Anticoagulants (blood thinners) to prevent blood clots, especially with prosthetic valves

Surgical and Interventional Treatment

In severe cases of heart valve disease, a procedure is often necessary:

Valve repair: The patient's own valve is surgically repaired. This is the preferred approach when feasible.
Valve replacement: The damaged valve is replaced with a mechanical (metal) or biological (animal tissue) prosthesis.
Catheter-based procedures: Minimally invasive techniques such as TAVI (Transcatheter Aortic Valve Implantation) allow valve replacement without open-heart surgery, particularly beneficial for elderly or high-risk patients.
Balloon valvuloplasty: A balloon catheter is used to widen a narrowed heart valve.

Prognosis and Outlook

The course of heart valve disease varies greatly between individuals. Mild forms may remain stable for many years and require only regular monitoring. However, severe untreated valve disease can lead to heart failure, stroke, or life-threatening arrhythmias. With timely and appropriate treatment, the prognosis is generally favorable in many cases.

References

Vahanian A et al. – 2021 ESC/EACTS Guidelines for the management of valvular heart disease. European Heart Journal, 2022; 43(7): 561–632.
Otto CM et al. – 2020 ACC/AHA Guideline for the Management of Patients with Valvular Heart Disease. Journal of the American College of Cardiology, 2021; 77(4): e25–e197.
Bonow RO et al. – Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier, 2021.

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