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Hyperpigmentation: Causes, Symptoms and Treatment

Hyperpigmentation refers to a darkening of the skin caused by excess melanin production. It is usually harmless but can sometimes indicate an underlying condition.

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Things worth knowing about "Hyperpigmentation"

Hyperpigmentation refers to a darkening of the skin caused by excess melanin production. It is usually harmless but can sometimes indicate an underlying condition.

What is Hyperpigmentation?

Hyperpigmentation is a common skin condition in which certain areas of the skin appear darker than the surrounding normal skin. This occurs due to an overproduction of melanin, the natural pigment responsible for skin, hair, and eye color, which is produced by specialized skin cells called melanocytes. Hyperpigmentation can affect any part of the body but is most commonly seen on sun-exposed areas such as the face, hands, décolleté, and shoulders.

Causes

Several factors can trigger excessive melanin production:

UV radiation: Sun exposure is the most common cause. Chronic exposure leads to the formation of age spots (solar lentigines).
Hormonal changes: Pregnancy, hormonal contraceptives, or hormonal disorders can cause melasma (also known as chloasma) – patchy discoloration most commonly on the face.
Skin inflammation: Acne, wounds, burns, or eczema can result in post-inflammatory hyperpigmentation (PIH) once the inflammation resolves.
Medications: Certain antibiotics, chemotherapy agents, or antimalarials may cause pigment changes as a side effect.
Medical conditions: Conditions such as Addison disease or hemochromatosis can lead to widespread hyperpigmentation.
Genetic factors: Freckles (ephelides) are genetically determined and become more prominent with sun exposure.

Types of Hyperpigmentation

Melasma (Chloasma)

Symmetrically distributed, brown to grey-brown patches, primarily on the face. Melasma is especially common in women during pregnancy or while taking hormone therapy. UV exposure significantly worsens the discoloration.

Post-Inflammatory Hyperpigmentation

This type develops following skin inflammation or injury. It is particularly prevalent in individuals with darker skin tones and often appears in areas previously affected by acne or burns.

Age Spots (Solar Lentigines)

Well-defined, flat, brown spots on sun-exposed skin. They develop as a result of cumulative UV exposure and typically appear from middle age onward.

Freckles (Ephelides)

Small, round, light-brown spots that are genetically determined and intensify with sun exposure. They are entirely harmless.

Diagnosis

Diagnosis is typically made through a clinical examination by a dermatologist. Dermatoscopy (dermoscopy) allows assessment of pigment distribution in deeper skin layers. A Wood lamp examination uses ultraviolet light to distinguish between epidermal and dermal pigmentation. If a systemic cause is suspected, blood tests (e.g., hormone levels, iron levels) may be ordered.

Treatment

Treatment depends on the underlying cause and the severity of the condition. The most important baseline measure for all forms of hyperpigmentation is consistent sun protection (SPF 30–50+).

Topical (Externally Applied) Treatments

Hydroquinone: The gold standard in depigmentation therapy; inhibits melanin synthesis. Should only be used under medical supervision.
Azelaic acid: Anti-inflammatory and pigment-reducing; well tolerated and suitable for use during pregnancy.
Vitamin C (ascorbic acid): An antioxidant that inhibits melanin formation and brightens the skin.
Retinol / Tretinoin: Promote skin cell turnover and reduce the appearance of pigmentation.
Kojic acid, arbutin, niacinamide: Plant-derived or synthetic brightening agents with good tolerability.

Professional Procedures

Chemical peels: Alpha-hydroxy acid or TCA peels remove superficial pigmentation layers.
Laser therapy: Pulsed laser systems (e.g., Q-switched Nd:YAG laser) target pigmented lesions precisely.
Microdermabrasion: Mechanical exfoliation of the outermost skin layer.
Intense pulsed light (IPL): Broad-spectrum light used to reduce pigment spots.

Prevention

The most effective preventive measure is consistent protection against UV radiation: broad-spectrum sunscreen with a high SPF, protective clothing, and avoiding direct sunlight during peak hours (10 a.m. to 4 p.m.). For hormonally induced hyperpigmentation, adjusting or changing the hormone therapy may help prevent further darkening.

References

Passeron T. et al. - Position statement on the use of depigmenting agents in melasma and post-inflammatory hyperpigmentation. Journal of the European Academy of Dermatology and Venereology, 2022.
Miot LDB, Miot HA, Silva MG, Marques ME. - Physiopathology of melasma. Anais Brasileiros de Dermatologia, 2009;84(6):623-35.
Handel AC, Miot LD, Miot HA. - Melasma: a clinical and epidemiological review. Anais Brasileiros de Dermatologia, 2014;89(5):771-782.

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