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Ketoacidosis – Dangerous Metabolic State in Diabetes

Ketoacidosis is a life-threatening condition caused by excess ketones. Learn how it develops, its symptoms and when urgent treatment is needed.

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Things worth knowing about "Ketoacidosis"

Die Ketoazidose ist eine akute Stoffwechselentgleisung, bei der sich im Körper große Mengen Ketonkörper ansammeln.

Ketonkörper entstehen, wenn Zellen auf Fettverbrennung umschalten, z. B. bei Insulinmangel, Hungerzuständen oder extremen Low-Carb-Diäten. Besonders gefährlich ist sie bei Diabetes Typ 1, wenn kein Insulin verfügbar ist, dann gerät der Stoffwechsel außer Kontrolle.

Überschüssige Ketone – vor allem Acetessigsäure und β-Hydroxybutyrat – senken den pH-Wert des Blutes, was zu einer metabolischen Azidose führt. Symptome sind ÜbelkeitErbrechenBauchschmerzentiefe Atmung (Kussmaul-Atmung), Bewusstseinsstörungen und süßlicher Acetongeruch. Ohne Therapie kann die Ketoazidose schnell lebensbedrohlich werden.

Früherkennung ist entscheidend: Bei erhöhtem Blutzucker, fehlender Insulingabe, Infekten oder Fastenzuständen sollte auf Ketone im Urin oder Blut geachtet werden. Eine ausgewogene Ketose, etwa durch kontrollierte Ernährung oder therapeutisches Fasten, unterscheidet sich klar von einer Ketoazidose

Gesundheitliche Aspekte der Ketoazidose

  • Tritt vor allem bei Typ-1-Diabetikern durch Insulinmangel auf
  • Führt zu pH-Abfall im Blut, starker Übersäuerung und Bewusstseinsstörungen
  • Symptome: ÜbelkeitErbrechentiefe Atmung
  • Unterschied zur physiologischen Ketose bei Diät oder Fasten 

Literaturangaben:

  • Kitabchi, A. E. et al. (2009). Hyperglycemic crises in adult patients with diabetes. Diabetes Care.
  • Gosmanov, A. R. et al. (2014). Diabetic ketoacidosis: treatment and complications. Endocrinology and Metabolism Clinics.
  • Moreno-Navarrete, J. M. et al. (2013). Lactoferrin attenuates the deleterious effects of obesity-associated inflammation in human adipose tissue. International Journal of Obesity.

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