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Neurogenic: Meaning, Causes and Treatment

Neurogenic refers to anything originating from or caused by the nervous system. In medicine, the term describes conditions, pain, or dysfunction of nervous origin.

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Things worth knowing about "Neurogenic"

Neurogenic refers to anything originating from or caused by the nervous system. In medicine, the term describes conditions, pain, or dysfunction of nervous origin.

What does neurogenic mean?

The adjective neurogenic derives from the Greek words neuron (nerve) and genesis (origin, creation). In medicine, it describes all processes, conditions, or diseases that originate in the nervous system or are triggered by nerve activity. The term may apply to both the central nervous system (brain and spinal cord) and the peripheral nervous system.

Medical Uses of the Term

The term neurogenic is used across many medical specialties to describe different phenomena:

Neurogenic pain (neuropathic pain): Pain caused directly by damage or dysfunction of nerve fibers, for example in polyneuropathy or following a stroke.
Neurogenic bladder: Dysfunction of the urinary bladder due to nerve damage, as seen in multiple sclerosis, spinal cord injuries, or diabetes.
Neurogenic shock: A life-threatening condition caused by a sudden disruption of the autonomic nervous system, for example after severe spinal cord injuries.
Neurogenic inflammation: An inflammatory response triggered by the release of neuropeptides from nerve endings.
Neurogenic tumors: Tumors arising from nerve cells or nerve tissue, such as neurofibromas or schwannomas.

Causes of Neurogenic Conditions

Neurogenic conditions and symptoms can be triggered by many different factors:

Traumatic injuries to the spinal cord or peripheral nerves
Degenerative diseases such as amyotrophic lateral sclerosis (ALS) or multiple sclerosis
Metabolic diseases, particularly diabetes mellitus, which can damage nerves (diabetic neuropathy)
Infections (e.g., herpes zoster, HIV)
Toxic effects from alcohol, chemicals, or medications
Congenital malformations of the nervous system
Tumors pressing on or growing into nerve tissue

Symptoms of Neurogenic Conditions

The symptoms of neurogenic conditions vary widely and depend on which part of the nervous system is affected:

Sensory disturbances: Numbness, tingling, burning sensations, or abnormal sensations (paresthesias)
Motor disturbances: Muscle weakness, paralysis, or involuntary muscle twitching
Autonomic disturbances: Bladder or bowel problems, blood pressure fluctuations, abnormal sweating
Chronic pain: Often burning, stabbing, or shooting in character, typical of neurogenic pain syndromes
Coordination problems: Balance disorders and changes in gait

Diagnosis of Neurogenic Conditions

The diagnosis of neurogenic conditions is made using a combination of methods:

Clinical examination: Neurological assessment including reflexes, sensation, and motor function
Electrophysiological tests: Electromyography (EMG) and nerve conduction studies (NCS) to evaluate nerve and muscle function
Imaging: MRI (magnetic resonance imaging) or CT (computed tomography) to visualize the nervous system and surrounding structures
Laboratory tests: Blood tests to identify potential causes (e.g., blood glucose, vitamin deficiencies, inflammatory markers)
Lumbar puncture: Analysis of cerebrospinal fluid when inflammatory conditions are suspected

Treatment of Neurogenic Conditions

Treatment depends on the underlying cause and the part of the nervous system affected:

Pharmacological therapy: Anticonvulsants (e.g., gabapentin, pregabalin) or antidepressants for neurogenic pain; immunosuppressants for inflammatory conditions
Physiotherapy: To improve strength, coordination, and mobility
Occupational therapy: Supporting daily activities and maintaining independence
Interventional procedures: Nerve blocks or spinal cord stimulation for chronic pain
Treatment of the underlying condition: For example, optimizing blood sugar control in diabetic neuropathy
Rehabilitation: Comprehensive care for patients with severe neurological damage

References

Mumenthaler, M. & Mattle, H. (2021). Neurology. 13th edition. Thieme Verlag, Stuttgart.
International Association for the Study of Pain (IASP). Neuropathic Pain -- Special Interest Group. Available at: https://www.iasp-pain.org/SIG/NeuropathicPain/
World Health Organization (WHO). Neurological disorders: public health challenges. Available at: https://www.who.int/mental_health/neurology/en/

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