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Neurohormone – Definition and Function

A neurohormone is a chemical messenger produced by nerve cells that regulates body functions such as mood, sleep, stress response, and metabolism.

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Things worth knowing about "Neurohormone"

A neurohormone is a chemical messenger produced by nerve cells that regulates body functions such as mood, sleep, stress response, and metabolism.

What Is a Neurohormone?

A neurohormone is a chemical messenger synthesized by specialized nerve cells (neurons) and released into the bloodstream or surrounding tissue fluid. Unlike classical hormones, which are secreted by endocrine glands, neurohormones originate directly within the nervous system. They form a critical link between the nervous system and the endocrine system, helping to regulate a wide range of physiological and psychological processes.

Production and Release

Neurohormones are primarily produced in the hypothalamus, a key regulatory center in the brain. Once synthesized, they are released into the bloodstream and travel to target organs throughout the body. This distinguishes them from classical neurotransmitters, which act locally within the synaptic cleft between two nerve cells and are not typically released into circulation.

Key Examples of Neurohormones

Oxytocin: Often called the bonding hormone; promotes social attachment, trust, and plays a vital role in childbirth and breastfeeding.
Vasopressin (ADH): Regulates the body water balance and blood pressure.
Melatonin: Controls the sleep-wake cycle (circadian rhythm); produced by the pineal gland.
Adrenaline and Noradrenaline: Stress hormones that trigger the fight-or-flight response in dangerous or exciting situations.
Dopamine: Involved in motivation, reward processing, and motor control.
Serotonin: Influences mood, appetite, and sleep; low levels are associated with depression.

Functions in the Body

Neurohormones perform a wide variety of essential functions, coordinating complex responses to both internal and external stimuli to keep the body and mind in balance.

Regulation of mood and emotional well-being
Control of the sleep-wake cycle
Management of hunger, thirst, and satiety
Modulation of stress responses and immune function
Regulation of blood pressure and fluid balance
Coordination of reproductive behavior and social bonding

Clinical Significance

Imbalances in neurohormone levels can contribute to a variety of medical conditions. Disruptions in serotonin and dopamine signaling are associated with depression, anxiety disorders, and Parkinson disease. A deficiency of vasopressin can lead to diabetes insipidus, a condition characterized by excessive urination. Elevated adrenaline levels may indicate a pheochromocytoma, a tumor of the adrenal medulla.

Many modern therapies are based on targeted modulation of neurohormones. For example, antidepressants such as selective serotonin reuptake inhibitors (SSRIs) work by increasing serotonin availability in the brain.

Diagnosis of Neurohormone Disorders

Several diagnostic approaches are available to evaluate neurohormone imbalances:

Blood tests: Measurement of hormone concentrations in the blood serum
Urine analysis: Detection of metabolic breakdown products of certain neurohormones (e.g., catecholamines)
Imaging procedures: MRI or CT scans to visualize brain structures such as the hypothalamus or pineal gland
Function tests: Stimulation or suppression tests to assess hormonal axes

References

Kandel, E.R. et al. (2021): Principles of Neural Science, 6th edition. McGraw-Hill Education, New York.
Boron, W.F. & Boulpaep, E.L. (2017): Medical Physiology, 3rd edition. Elsevier, Philadelphia.
World Health Organization (WHO): Mental Health and Brain Disorders. Available at: https://www.who.int/health-topics/mental-health

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