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Nigerose – Disaccharide with Prebiotic Properties

Nigerose is a naturally occurring disaccharide composed of two glucose units. It is found in certain foods and exhibits prebiotic properties that may support gut health.

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Things worth knowing about "Nigerose"

Nigerose is a naturally occurring disaccharide composed of two glucose units. It is found in certain foods and exhibits prebiotic properties that may support gut health.

What is Nigerose?

Nigerose is a naturally occurring disaccharide consisting of two glucose units linked by an alpha-1,3-glycosidic bond. The name is derived from the mold Aspergillus niger, from which the compound was first isolated. Nigerose is present in small amounts in certain foods, including honey, sake (Japanese rice wine), and various fermented products.

Chemical Properties

Nigerose belongs to the group of reducing disaccharides. Its chemical structure differs from other well-known disaccharides such as maltose (alpha-1,4 bond) or isomaltose (alpha-1,6 bond) due to the characteristic alpha-1,3-glycosidic bond. This unique linkage makes the molecule resistant to certain digestive enzymes in the human body, conferring prebiotic properties upon it.

Food Sources

Honey: Nigerose is one of the naturally occurring sugar components found in various types of honey.
Sake and Amazake: Fermented Japanese rice beverages contain measurable amounts of nigerose.
Fermented foods: Products fermented with molds may contain low concentrations of nigerose.
Black garlic: Traces of nigerose have also been detected in fermented black garlic.

Biological Functions and Prebiotic Effects

Because nigerose is only partially broken down by human digestive enzymes in the small intestine, a portion of the ingested sugar reaches the large intestine intact. There it serves as a substrate for beneficial gut bacteria, functioning as a prebiotic. Studies suggest that nigerose can promote the growth of Bifidobacteria and Lactobacilli, thereby contributing to a healthy gut microbiome.

Potential Health Benefits

Gut health support: As a prebiotic, nigerose can positively influence the composition of the gut microbiome.
Low glycemic index: Due to its resistance to digestion, nigerose causes a slower rise in blood sugar levels compared to regular sugar.
Antioxidant properties: Some studies indicate an antioxidant potential of nigerose, which may help reduce oxidative stress.
Immune modulation: Preliminary research suggests possible immunomodulatory effects, although the evidence base remains limited at present.

Applications and Uses

In the food industry, nigerose is increasingly being researched as a functional sweetener. Since it provides moderate sweetness while also delivering prebiotic effects, it is considered a potentially interesting alternative to conventional table sugar (sucrose) and other sweeteners. In Japan, nigerose is already used in some functional foods and dietary supplements.

In scientific research, nigerose also serves as a starting material for synthesizing more complex oligosaccharides and is used in enzymology to study specific glycosidic bond interactions.

Safety and Tolerability

Nigerose is considered safe and well-tolerated in the amounts typically found in foods. Since it is fermented in the large intestine, sensitive individuals or those consuming large amounts may occasionally experience mild gastrointestinal symptoms such as bloating or a feeling of fullness. People with existing digestive conditions should exercise caution when consuming larger quantities.

References

Mukai, K. et al. (2017): Nigerose suppresses the IgE-mediated degranulation of RBL-2H3 cells and passive cutaneous anaphylaxis in mice. Bioscience, Biotechnology, and Biochemistry, 81(4), 761-768.
Ye, X. et al. (2019): Biological activities and potential health benefits of nigerose and nigerooligosaccharides. Journal of Functional Foods, 54, 229-237.
Nihira, T. et al. (2014): Discovery of beta-1,3-glucosylglucose phosphorylase involved in nigerose degradation in Aspergillus niger. Journal of Biological Chemistry, 289(44), 30942-30950.

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