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Threonine – Essential Amino Acid

Threonine is an essential amino acid that the human body cannot produce on its own and must obtain through diet. It plays a key role in protein synthesis, immune function, and gut health.

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Things worth knowing about "Threonine"

Threonine is an essential amino acid that the human body cannot produce on its own and must obtain through diet. It plays a key role in protein synthesis, immune function, and gut health.

What Is Threonine?

Threonine (also known as L-threonine) is an essential amino acid, meaning the human body is unable to synthesize it and must obtain it through dietary sources. Amino acids are the fundamental building blocks of all proteins in the body and serve a wide range of vital functions. Threonine is a proteinogenic amino acid found in many animal and plant-based foods.

Biological Functions

Threonine performs numerous important roles in the human body:

Protein synthesis: Threonine is a component of many structural proteins and enzymes, making it essential for tissue growth and repair.
Immune support: The amino acid contributes to the production of antibodies, thereby supporting the body´s natural defenses.
Gut barrier protection: Threonine is a key component of mucins – the mucus proteins that protect the lining of the gastrointestinal tract and help maintain intestinal barrier integrity.
Collagen synthesis: As a precursor to glycine, threonine contributes to the formation of collagen and elastin, which are vital for skin, bones, and connective tissue.
Fat metabolism: Threonine exerts a lipotropic effect in the liver, meaning it helps prevent excessive fat accumulation in liver tissue.
Nervous system: Threonine is involved in the synthesis of glycine, an inhibitory neurotransmitter in the central nervous system.

Dietary Sources

Threonine is found in many protein-rich foods. Particularly good sources include:

Meat and poultry (e.g., beef, chicken, pork)
Fish and seafood
Eggs and dairy products (e.g., cheese, cottage cheese, yogurt)
Legumes (e.g., lentils, chickpeas, soybeans)
Nuts and seeds
Grains (e.g., wheat, quinoa)

Recommended Intake

The World Health Organization (WHO) recommends a daily intake of approximately 15 mg of threonine per kilogram of body weight for adults. For a person weighing 70 kg, this corresponds to roughly 1,050 mg per day. A balanced, protein-rich diet typically provides sufficient amounts to meet this requirement.

Deficiency Symptoms

A threonine deficiency is rare in Western countries but can occur with severely restricted diets, malabsorption syndromes, or extreme dietary patterns. Possible signs of deficiency include:

Muscle weakness and loss of muscle mass
Impaired immune function and increased susceptibility to infections
Digestive disturbances and intestinal mucosal problems
Delayed wound healing
Mood changes and difficulty concentrating

Toxicity and Safety

Excessive threonine intake through regular food consumption is unlikely. However, very high doses taken as dietary supplements may cause side effects including nausea, gastrointestinal discomfort, and in rare cases, liver function disturbances. Medical advice should be sought before taking high-dose threonine supplements.

Threonine as a Dietary Supplement

Threonine supplements are used in a number of contexts:

Supporting gut health and strengthening the intestinal barrier
Promoting muscle growth in athletic settings
Adjunct therapy for certain neurological conditions (e.g., spastic paralysis – under medical supervision)
Supplementation for individuals following vegan or vegetarian diets with potentially lower dietary intake

References

World Health Organization (WHO): Protein and Amino Acid Requirements in Human Nutrition. WHO Technical Report Series, No. 935. Geneva, 2007.
Hou Y, Wu G: Nutritionally Essential Amino Acids. Advances in Nutrition, 2017; 8(6): 887–888. PubMed PMID: 29141979.
Reeds PJ: Dispensable and Indispensable Amino Acids for Humans. Journal of Nutrition, 2000; 130(7): 1835S–1840S. PubMed PMID: 10867060.

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