-
DE
Tricyclic Antidepressants – Mechanism, Uses & Side Effects
Learn about tricyclic antidepressants: how they work, their use in depression and pain, and common side effects compared to modern drugs.
Add as Preferred SourceThings worth knowing about "Tricyclic antidepressants (TCAs)"
Tricyclic antidepressants (TCAs) are among the oldest classes of antidepressants, developed in the 1950s.
TCAs work by blocking the reuptake of serotonin and norepinephrine, increasing their concentrations in the brain. TCAs also affect other neurotransmitters such as histamine and acetylcholine, which explains their broad efficacy as well as their side effect profile.
TCAs are used to treat moderate to severe depression, but also chronic pain, anxiety disorders, and sleep disturbances. Common examples include amitriptyline, imipramine, and nortriptyline. Because they act on multiple neurotransmitter systems, they can have mood-enhancing, sedative, and analgesic properties.
However, TCAs are associated with relatively frequent side effects, including dry mouth, weight gain, fatigue, cardiac arrhythmias, and blood pressure fluctuations. Today, they are generally prescribed when modern antidepressants (e.g., SSRIs, SNRIs) are ineffective. Supportive natural approaches such as exercise, diet, mindfulness, and herbal remedies may further promote mental well-being.
Key Facts about TCAs
- Oldest antidepressant class, act via serotonin and norepinephrine reuptake inhibition
- Used for depression, chronic pain, and anxiety disorders
- Higher risk of side effects, often used in treatment-resistant cases
Building Blocks for a Healthy Life
As an integrated manufacturer, we develop & produce evidence-based, patented, and non-patented formulations. We work exclusively with plant and natural extracts according to the strictest purity & quality standards.
The combination of science & modern technology with the laws of nature creates solutions consistently tailored to humans – for the highest good: health.
Skip product gallery
Subscription available
Floral
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, lactic acid bacteria, and Lactoferrin CLN®30 lozenges
Regular price:
€22.90
Discount
Subscription available
Lactoferrin 60 Capsules
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
60 Capsules
Sale price:
€50.00
Regular price:
€59.90
Subscription available
Multivitamin Mineral Complex
Daily basic supply: the complete spectrum of micronutrients
Natural multivitamin complex for the immune system, energy, and central body functions
30 Capsules
Regular price:
€29.90
Subscription available
Natural Iron
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
30 Capsules
Regular price:
€35.90
Most read entries
3 Posts in this encyclopedia categoryMagnesiumcarbonat
Magnesiumcarbonat ist eine anorganische Magnesiumverbindung mit säure-neutralisierender (antazidischer) Wirkung. Erfahre mehr über Vorteile, Einsatzgebiete und Unterschiede zu besser resorbierbaren Magnesiumformen.
Calorie content
The choice of food influences our energy intake. The calorie content varies greatly - some provide little energy, others a lot.
Cologne list
The Cologne List ® is an important initiative in competitive sports that offers athletes guidance in the selection of nutritional supplements.