Diamine oxidase (DAO) - function, histamine degradation & histamine intolerance

Diamine oxidase (DAO) is an enzyme that plays a crucial role in the breakdown of histamine in the body.

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Diamine oxidase (DAO) is an enzyme that plays a crucial role in the breakdown of histamine in the body.

Histamine is a substance that is released during allergic reactions, but is also found in many foods, especially in matured or fermented foods. Insufficient DAO activity means that histamine cannot be broken down efficiently in the body, which can lead to histamine intolerance. In histamine intolerance, high levels of histamine accumulate in the body, leading to various symptoms such as headaches, reddening of the skin, indigestion or breathing difficulties. Sufficient DAO production is therefore essential for the metabolism of histamine. Taking DAO supplements can help to alleviate the symptoms of histamine intolerance by supporting the body's ability to process histamine, preventing it from accumulating in the body.