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Urethra - Anatomy, Function and Conditions

The urethra is the tube that carries urine from the bladder out of the body. It is a key part of the urinary tract and differs in length between males and females.

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Things worth knowing about "Urethra"

The urethra is the tube that carries urine from the bladder out of the body. It is a key part of the urinary tract and differs in length between males and females.

What is the Urethra?

The urethra is a tubular channel that connects the urinary bladder to the outside of the body, allowing urine to be expelled. It is an essential part of the lower urinary tract and plays a different anatomical role in males and females.

Anatomy of the Urethra

Female Urethra

In females, the urethra is significantly shorter, measuring approximately 3 to 5 centimeters in length. It runs directly from the bladder neck to the external urethral opening (meatus urethrae externus), which is located just in front of the vaginal opening. Due to its short length, women are more susceptible to ascending urinary tract infections.

Male Urethra

In males, the urethra is considerably longer, measuring approximately 18 to 22 centimeters. It is divided into several segments:

  • Prostatic urethra (pars prostatica): passes through the prostate gland
  • Membranous urethra (pars membranacea): traverses the pelvic floor
  • Spongy urethra (pars spongiosa / penile urethra): runs through the penis to the external opening

In males, the urethra serves a dual function: it transports both urine and semen, though not simultaneously.

Function of the Urethra

The primary function of the urethra is the controlled drainage of urine from the body. Two sphincter muscles regulate this process:

  • Internal sphincter: composed of smooth muscle, involuntarily controlled
  • External sphincter: composed of striated muscle, voluntarily controlled

In males, the urethra also plays a role in reproduction by serving as a shared conduit for urine and seminal fluid.

Common Conditions Affecting the Urethra

Urethritis

Urethritis is an inflammation of the urethra, most commonly caused by bacterial infections. Sexually transmitted pathogens such as Chlamydia trachomatis and Neisseria gonorrhoeae are frequent causes. Symptoms include a burning sensation during urination, discharge, and itching.

Urethral Stricture

A urethral stricture is a narrowing of the urethra that obstructs urine flow. It can result from scar tissue following injury, infection, or medical procedures. Symptoms include a weak urine stream, pain, and incomplete bladder emptying.

Urethral Cancer

Urethral cancer is a rare malignancy. Symptoms may include blood in the urine (hematuria), pain during urination, and a palpable mass in the urethral region.

Hypospadias and Epispadias

These are congenital malformations affecting the position of the urethral opening. In hypospadias, the opening is located on the underside of the penis; in epispadias, it is located on the upper side.

Diagnosis of Urethral Conditions

Several diagnostic methods are available to evaluate the urethra:

  • Urinalysis and urine culture: detection of infection or blood in urine
  • Urethrocystoscopy: direct visualization of the urethra using an endoscope
  • Uroflowmetry: measurement of urine flow rate to detect narrowing
  • Retrograde urethrography: X-ray imaging with contrast dye to visualize the urethra
  • Urethral swab: collection of secretions for microbiological analysis in suspected infections

Treatment of Urethral Conditions

Treatment depends on the specific condition:

  • Urethritis: Antibiotic therapy targeted at the identified pathogen
  • Urethral stricture: Dilation (bougieurage), urethrotomy, or surgical reconstruction (urethroplasty)
  • Urethral cancer: Surgical resection, potentially combined with radiation or chemotherapy
  • Congenital malformations: Surgical correction, typically performed in childhood

References

  1. Wein, A.J. et al. (2016). Campbell-Walsh Urology, 11th Edition. Elsevier Saunders.
  2. European Association of Urology (EAU) (2023). EAU Guidelines on Urological Infections. Available at: https://uroweb.org/guidelines/urological-infections
  3. Drake, R.L., Vogl, A.W. & Mitchell, A.W.M. (2019). Gray's Anatomy for Students, 4th Edition. Elsevier.

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