Immunoglobulins (Ig) - antibodies for immune protection, allergies and diagnostics

Immunoglobulins are antibodies of the immune system that recognise and fight pathogens. They are crucial for defence against infections, allergies and modern immunotherapies.

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Wissenswertes über "Immunoglobulins (Ig)"

Immunoglobulins (Ig) - also known as antibodies - are specialised proteins that are produced by the immune system to specifically recognise pathogens such as bacteria, viruses or fungi and render them harmless.

Immunoglobulins are produced by B cells (plasma cells) and are a central component of the specific (adaptive) immune defence. They circulate in the blood and mucous membranes, recognise foreign structures (antigens) and mark them for other immune cells.

There are five main classes with different functions:

IgG: Most common antibody in the blood, provides long-term protection after infections or vaccinations, placental.
IgA: Predominantly found in mucous membranes and secretions (e.g. saliva, tears, breast milk), protects against pathogens at ports of entry.
IgM: Formed as the first antibody in acute infections
IgE: Plays a central role in allergies and parasite defence
IgD: Occurs in small amounts, function not yet fully understood.

In medical diagnostics, immunoglobulins serve as markers for acute or chronic infections, immune diseases or allergies. Certain patterns, e.g. increased IgE levels in allergies or a lack of IgA, can indicate autoimmune diseases, chronic or immunodeficiencies. They also play an important role in Covid-19, vaccination reactions or immunotherapies. Immunoglobulin preparations are also gaining therapeutic importance in immunology - for example as IVIG (intravenous immunoglobulins) for autoimmune diseases or for passive immunisation. The combination of antibodies with targeted therapy is also used in cancer immunotherapy or monoclonal antibody therapy.

Important properties of immunoglobulins:

Antibodies of the adaptive immune system
Recognition and binding of antigens
Classes: IgG, IgA, IgM, IgE, IgD
Application in diagnostics, vaccinations, allergy tests, immunotherapies
Therapeutically usable as IVIG or monoclonal antibodies

Literature references

Janeway, C. A. et al (2022). ""Immunobiology - The Immune System in Health and Disease.""
Abbas, A. K. et al. (2021). ""Cellular and Molecular Immunology.""
Paul, W. E. (2012). ""Fundamental Immunology.""