Tachyphylaxis – When Drugs Lose Their Effect Rapidly

Tachyphylaxis is the rapid loss of drug response after repeated use. Common with nasal sprays, antidepressants and hormone therapy.

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Wissenswertes über "Tachyphylaxis"

Tachyphylaxis refers to the rapid loss of efficacy of a drug after repeated use, typically within hours to days.

Unlike gradual drug tolerance, tachyphylaxis develops suddenly and is often seen with nasal decongestants, antidepressants (SSRIs), beta-blockers, and hormonal agents.

The underlying cause is usually receptor desensitization or downregulation—meaning fewer receptors are available or responsive. As a result, patients may no longer experience therapeutic benefits despite consistent dosage. For example, nasal sprays can lead to rebound congestion due to overuse and tachyphylaxis.

Preventing tachyphylaxis involves treatment breaks, drug rotation, or switching to non-pharmacological options. In the case of SSRIs, tachyphylaxis may indicate adaptive changes in CNS receptors and require therapeutic reassessment.

Medical Implications of Tachyphylaxis

Sudden loss of drug effect despite unchanged dosing
Common with nasal sprays, antidepressants, hormones, beta-blockers
Caused by receptor desensitization or reduced receptor availability
Avoidable through intermittent use or switching medications
May signal need for clinical reevaluation in psychiatric or endocrine therapy

Literature references:

Gainetdinov, R. R. et al. (2004). Desensitization of G protein–coupled receptors and neuronal functions. Annual Review of Neuroscience.
Benedetti, F. et al. (2022). Antidepressant tachyphylaxis: Clinical relevance and underlying mechanisms. Frontiers in Pharmacology.
Eccles, R. (2007). Mechanisms of the symptoms of rhinitis. Clinical & Experimental Allergy.

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Verwandte Suchbegriffe: Tachyphylaxis

Tachyphylaxis – When Drugs Lose Their Effect Rapidly

Wissenswertes über "Tachyphylaxis"

Medical Implications of Tachyphylaxis

Die neusten Einträge

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Cold Leg Wraps

Sleep paralysis

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