Glossar (Lexikon)
Do you have questions about individual ingredients? You'll find a list of terms used in our ingredient glossary.
Wissenswertes über "tTF-NGR (truncated Tissue Factor)"
tTF-NGR is a fusion protein for targeted tumour therapy via vascular occlusion. Find out everything about the mechanism of action, application in cancer and current studies such as TRABTRAP.
tTF-NGR is a biotechnologically produced fusion protein that specifically targets tumour-associated vessels. It combines two functional units:
- tTF (truncated tissue factor): a truncated form of human tissue factor that can activate blood clotting
- NGR peptide (Asn-Gly-Arg): a tumour-homing sequence that binds specifically to CD13-positive endothelial cells
selectively induce microthrombosis in tumour vessels, thereby interrupting the tumour's blood supply and cutting off the cancer cells from nutrient replenishment.
targeted antiangiogenic therapy for difficult-to-treat tumours, in particular:
- Soft tissue sarcomas (e.g. in the TRABTRAP study in combination with trabectedin)
- Colorectal carcinoma
- Hepatocellular carcinoma
tumour regression while maintaining systemic tolerability.
Advantages:
- Challenges:
- innovative drug approach that uses vascular occlusion therapeutically to selectively starve tumours. Thanks to its tumour selectivity, it offers the chance of effective yet tolerable therapies for aggressive cancers.
Literature references:
- Cancer Cell.
- Journal of Clinical Oncology.
- Nature Biotechnology.
- innovative drug approach that uses vascular occlusion therapeutically to selectively starve tumours. Thanks to its tumour selectivity, it offers the chance of effective yet tolerable therapies for aggressive cancers.
Literature references:
- Cancer Cell.
- Journal of Clinical Oncology.
- Nature Biotechnology.
Meistgekaufte Produkte
For your iron balance
Specially formulated for your iron balance with plant-based curry leaf iron, Lactoferrin CLN®, and natural Vitamin C from rose hips.
For your universal protection
As one of the most valuable proteins in the body, lactoferrin is a natural component of the immune system.
For Healthy Oral Flora & Dental Care
Formulated lozenges with Dentalac®, probiotic lactic acid bacteria, and Lactoferrin CLN®The latest entries
3 Posts in this encyclopedia categoryMost read entries
3 Posts in this encyclopedia categoryMagnesiumcarbonat
Calorie content
Cologne list
Related search terms: tTF-NGR (truncated Tissue Factor)-en