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CD13 - cell surface enzyme with significance in tumour biology, inflammation and drug development
CD13 is an enzyme on cell surfaces that plays a central role in cancer, inflammation and immune processes. Find out more about its function, tumour biology and therapeutic target structures.
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CD13 is an enzyme on cell surfaces that plays a central role in cancer, inflammation and immune processes. Find out more about its function, tumour biology and therapeutic target structures.
CD13, also known as Aminopeptidase N (APN), is a transmembrane enzyme that occurs on the surface of numerous cell types - in particular on myelocytes, endothelial cells, epithelial cells and tumour cells. It belongs to the family of zinc-dependent metalloproteases and plays an important role in the cleavage of peptides, cell migration, angiogenesis and immune regulation.
tumour tissues, especially in:
- Soft tissue sarcomas
- Colorectal carcinomas
- Lung cancer
- Liver cell carcinoma
target molecule for tumour therapies. In the TRABTRAP study, for example, the tumour-specific peptide tTF-NGR is used, which binds to CD13 to selectively close the tumour vasculature and kill cancer cells through oxygen deprivation.
tumour-associated vascular endothelial cells, but not on normal blood vessels, CD13 provides a platform for targeted drug delivery. Therapeutic substances or nanoparticles are provided with CD13-ligating molecules such as NGR peptides in order to selectively target tumour tissue.
biomolecular marker to identify certain types of cancer or inflammatory conditions.
receptor for certain coronaviruses (not SARS-CoV-2) and is involved in the pathogenesis of some virus-induced diseases.
Literature references:
- Trends in Molecular Medicine.
- Journal of Clinical Investigation.
- "CD13 as a molecular target in cancer therapy." Oncological research up to date.
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