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Liposarcoma - malignant fatty tissue tumour: forms, diagnosis and therapy

Liposarcomas are rare malignant fatty tissue tumours with various subtypes. Find out more about symptoms, diagnosis, treatment and current research on sarcoma therapy.

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Things worth knowing about "Liposarcoma"

Liposarcomas are rare malignant fatty tissue tumours with various subtypes;

liposarcoma is a elderly, malignant tumour that arises from fatty tissue. It belongs to the group of soft tissue sarcomas and accounts for around 15-20% of this type of tumour in adults. Liposarcomas often develop deep in the tissue, particularly on the extremities, in the retroperitoneum (area behind the peritoneum) or in the trunk area.

slowly and with few symptoms, but can - depending on the subtype - be aggressive and grow into surrounding tissue or metastasise.

Well-differentiated liposarcoma (WDL): most common, slow-growing, low tendency to metastasise

Dedifferentiated liposarcoma (DDL): more aggressive, can metastasise

Myxoid liposarcoma: common in younger people, tends to metastasise early

Round cell liposarcoma: considered an aggressive subtype of myxoid liposarcoma

Pleiomorphic liposarcoma: very rare, highly malignant

Painless, increasing mass in deeper tissue

Pressure sensation, discomfort or dysfunction, depending on location

asymptomatic for a long time, often only conspicuous after large expansion

General symptoms such as weight loss or fever are rare and tend to be signs of advanced disease

MRI or CT for visualisation of expansion and infiltration

Biopsy for histological subtyping (essential for treatment planning)

Staging using chest CT due to possible lung metastases

Surgical removal with a wide safety margin is the most important measure

Radiation therapy before or after surgery for local control

Chemotherapy, especially for aggressive or metastasised subtypes

Clinical trials offer access to new forms of therapy, e.g. Targeted vascular occlusion in CD13-positive tumours (as in the TRABTRAP trial with tTF-NGR)

WDL has a good prognosis with a low metastasis rate but a high risk of recurrence

DDL, pleiomorphic or round cell subtypes: higher risk of distant metastases and poorer prognosis

follow-up examinations are essential to detect relapses at an early stage
.
Literature references:

""Liposarcoma: new entities and evolving concepts."" Annals of Diagnostic Pathology
.

""Soft tissue sarcomas: ESMO Clinical Practice Guidelines."" Annals of Oncology

""Patient information on liposarcoma.""

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Liposarcoma - malignant fatty tissue tumour: forms, diagnosis and therapy

Things worth knowing about "Liposarcoma"

Painless, increasing mass in deeper tissue

Pressure sensation, discomfort or dysfunction, depending on location

asymptomatic for a long time, often only conspicuous after large expansion

General symptoms such as weight loss or fever are rare and tend to be signs of advanced disease