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Wissenswertes über "Soft tissue sarcoma"
Soft tissue sarcomas are rare malignant tumours of the connective tissue
soft tissue sarcoma is a malignant tumour that arises from the mesenchymal tissue.strong data-start=""201"" data-end=""225"">mesenchymal tissue of the soft tissue - this includes connective, fatty, muscle, nerve, vascular and tendon sheath tissue. This type of tumour is rare, but accounts for around 1% of all malignant tumours in adults. There are over 50 histological subtypes, which can differ greatly in terms of growth, metastasis and response to treatment.
recognised late.
Typical signs are:
- Painless, progressive swelling or lump
- Restriction of movement when joints or nerves are affected
- Pain or discomfort, with increasing spread
- General symptoms such as fatigue, weight loss or fever are rare
sporadically, without a clear cause. Possible risk factors:
- Previous radiotherapy
- Genetic syndromes (e.g. Li-Fraumeni syndrome, neurofibromatosis type 1)
- Chronic inflammation or tissue damage
- CD13 expression, relevant for targeted therapies
- Previous radiotherapy
- Genetic syndromes (e.g. Li-Fraumeni syndrome, neurofibromatosis type 1)
- Chronic inflammation or tissue damage
- CD13 expression, relevant for targeted therapies
- additional therapy with tTF-NGR, a fusion protein that specifically closes tumour-supplying vessels via CD13
Literature references:
- ""Soft tissue sarcomas: ESMO-EURACAN Clinical Practice Guidelines."" Annals of Oncology.
- ""Patient guide for soft tissue sarcomas.""
- ""TRAPTRAP trial - Targeted vascular infarction in soft tissue sarcoma."" Journal of Clinical Oncology.
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