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Dimethylaminoethanol (DMAE) – Effects and Uses

Dimethylaminoethanol (DMAE) is a naturally occurring compound found in the brain and certain foods, known as a precursor to the neurotransmitter acetylcholine.

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Things worth knowing about "Dimethylaminoethanol"

Dimethylaminoethanol (DMAE) is a naturally occurring compound found in the brain and certain foods, known as a precursor to the neurotransmitter acetylcholine.

What is Dimethylaminoethanol?

Dimethylaminoethanol (DMAE), also known as deanol or by its abbreviation DMAE, is an organic compound naturally produced in small amounts in the human brain. It is also found in certain foods, particularly in fatty marine fish such as salmon, sardines, and anchovies. DMAE is widely used as a dietary supplement and also plays a role in the cosmetics industry.

Mechanism of Action

DMAE is considered a precursor molecule to choline and subsequently to acetylcholine, a key neurotransmitter in both the central and peripheral nervous systems. Acetylcholine plays a critical role in memory, learning, and neuromuscular function. DMAE is thought to increase acetylcholine production in the brain by crossing the blood-brain barrier and being converted into choline.

DMAE is also attributed with antioxidant properties. It is believed to reduce the accumulation of lipofuscin – a cellular waste product that builds up with age – thereby offering a degree of cellular protection.

Medical and Therapeutic Use

Cognitive Function and Mood

DMAE was previously used under the trade name Deanol as a prescription medication for behavioral disorders in children, including attention deficit hyperactivity disorder (ADHD). Some clinical studies have suggested positive effects on mood, concentration, and cognitive performance. However, the overall body of scientific evidence remains limited and inconclusive.

Sports Nutrition and Nootropics

In sports nutrition and the field of nootropics (brain-enhancing substances), DMAE is marketed as a means to improve mental clarity, focus, and physical endurance. Robust clinical evidence supporting these specific applications is largely lacking.

Cosmetic Application

In cosmetics, DMAE is used as an active ingredient in anti-aging products. It is claimed to increase skin firmness, reduce fine lines, and improve skin texture. Some studies suggest a short-term skin-tightening effect, which may be attributed to temporary swelling of skin cells.

Dietary Sources

DMAE is found in meaningful amounts in the following foods:

Salmon
Sardines
Anchovies
Herring
Other fatty marine fish

Dosage as a Dietary Supplement

As a dietary supplement, DMAE is commonly used in doses of 100 to 300 mg per day. It is available in capsule, tablet, and powder form. No official dosage recommendation has been issued by health authorities such as the WHO or EFSA. Use should therefore be discussed with a qualified healthcare professional.

Side Effects and Safety

DMAE is generally considered well tolerated when used as directed. Possible side effects include:

Headaches
Insomnia or vivid dreams
Muscle tension or muscle twitching
Irritability or restlessness
Elevated blood pressure at higher doses

Important note: DMAE is not recommended during pregnancy, as animal studies have indicated potential embryotoxic effects. Individuals with epilepsy or bipolar disorder should also avoid DMAE without prior medical consultation, as it may influence neuronal excitability.

Interactions

DMAE may interact with the following substances:

Anticholinergic medications: Since DMAE increases acetylcholine production, it may reduce the effectiveness of drugs that block acetylcholine activity (e.g., certain antihistamines, bladder medications).
Cholinesterase inhibitors: Combinations may lead to excessive acetylcholine activity.
Blood pressure medications: Possible additive effects on blood pressure levels.

References

Dimpfel W. et al. - Source and bioavailability of phosphatidylserine and DMAE as precursors for brain phospholipids - Nutritional Neuroscience, 2003.
Grossman R. - The role of dimethylaminoethanol in cosmetic dermatology - American Journal of Clinical Dermatology, 2005;6(1):39-47.
Haubrich DR, Gerber NH - Choline availability and the synthesis of acetylcholine - Journal of Neurochemistry, 1981;37(2):476-482.

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