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Monosodium Glutamate (E621) - Effects & Safety

Monosodium glutamate (MSG) is a food additive approved as E621 in the EU, widely used as a flavor enhancer in processed foods and restaurant cooking worldwide.

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Things worth knowing about "Monosodium glutamate"

Monosodium glutamate (MSG) is a food additive approved as E621 in the EU, widely used as a flavor enhancer in processed foods and restaurant cooking worldwide.

What is Monosodium Glutamate?

Monosodium glutamate (MSG) is the sodium salt of glutamic acid, a naturally occurring amino acid. In the European Union, it is approved as a food additive under the code E621. MSG is widely used in the food industry as a flavor enhancer, intensifying the so-called umami taste -- one of the five basic taste qualities, often described as savory, meaty, or brothy.

Production and Natural Occurrence

MSG is industrially produced mainly through microbial fermentation using bacteria such as Corynebacterium glutamicum, with starch-rich raw materials like sugar beets or cassava as the substrate. Glutamic acid occurs naturally in many protein-rich foods, including:

Tomatoes and tomato products
Parmesan and other aged cheeses
Mushrooms
Soy sauce and fish sauce
Meat and poultry

MSG itself is a white, odorless, crystalline powder. Its own taste is barely perceptible, but it significantly enhances the overall flavor of food.

Use in the Food Industry

MSG is used on a large scale in food production worldwide, particularly in:

Ready meals and instant noodles
Chips, snacks, and crackers
Seasoning blends and soups
Fast food and restaurant cooking (especially Asian cuisine)
Canned goods and frozen products

Under EU food law, MSG must be declared on ingredient lists, either as "monosodium glutamate" or as "E621".

Mechanism of Action: How Does MSG Work in the Body?

After ingestion, MSG is broken down into its components: sodium and glutamate. Glutamate is one of the most abundant excitatory neurotransmitters in the central nervous system and plays an important role in neural transmission. In the digestive tract, glutamate activates specific receptors on the tongue (known as mGluR and T1R1/T1R3 receptors), triggering the umami taste sensation. This is the mechanism underlying the flavor-enhancing properties of MSG.

Safety and Health Assessment

The safety of MSG has been evaluated by several international authorities:

The European Food Safety Authority (EFSA) established an acceptable daily intake (ADI) of 30 mg/kg body weight per day in 2017.
The Joint Expert Committee on Food Additives (JECFA) of WHO and FAO considers MSG safe at normal dietary consumption levels.
The U.S. Food and Drug Administration (FDA) classifies MSG as GRAS (Generally Recognized As Safe).

The term "Chinese Restaurant Syndrome" (also referred to as MSG symptom complex) was used to describe symptoms such as headaches, flushing, or palpitations following consumption of MSG-containing foods. However, controlled clinical studies have not established a clear causal link between MSG at typical dietary doses and these symptoms. This concept is now considered scientifically outdated and insufficiently supported by evidence.

Sodium Content and Nutritional Relevance

MSG contains approximately 12% sodium, compared to around 39% in conventional table salt (sodium chloride). Since MSG is more flavor-intense than salt, it can be used in smaller quantities to achieve the same taste result, which may theoretically contribute to sodium reduction in the diet. This is nutritionally relevant in the management of high blood pressure and cardiovascular disease.

References

EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) - Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621) as food additives. EFSA Journal, 2017.
World Health Organization (WHO) / FAO - Joint Expert Committee on Food Additives (JECFA): Monograph on Glutamic acid and its salts. Geneva, 2004.
U.S. Food and Drug Administration (FDA) - Questions and Answers on Monosodium Glutamate (MSG). fda.gov, 2023.

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