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Omentin – Adipokine, Metabolism & Health

Omentin is a hormone (adipokine) produced by adipose tissue that plays a key role in regulating metabolism and insulin sensitivity.

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Things worth knowing about "Omentin"

Omentin is a hormone (adipokine) produced by adipose tissue that plays a key role in regulating metabolism and insulin sensitivity.

What is Omentin?

Omentin (also known as Omentin-1 or Intelectin-1) is an adipokine – a signalling molecule produced by adipose (fat) tissue and released into the bloodstream. It is primarily secreted by visceral adipose tissue, the fat surrounding the internal organs in the abdominal cavity. First described in the early 2000s, omentin has since become an important subject of metabolic research due to its apparently protective role in human health.

Mechanism of Action

Omentin acts on multiple tissues and organs throughout the body. Its key known functions include:

Improving insulin sensitivity: Omentin enhances the effect of insulin in fat and muscle cells, facilitating the uptake of glucose (blood sugar).
Anti-inflammatory effects: The hormone inhibits pro-inflammatory signalling pathways, including suppression of the transcription factor NF-κB, thereby reducing chronic inflammation.
Cardiovascular protection: Omentin promotes vasodilation (widening of blood vessels) and may contribute to protection against cardiovascular disease.
Modulation of adipogenesis: There is evidence that omentin can influence the formation of new fat cells (adipogenesis).

Omentin and Disease

Numerous studies have demonstrated that blood omentin levels are altered in a variety of conditions:

Type 2 Diabetes and Insulin Resistance

People with type 2 diabetes and insulin resistance have consistently shown significantly lower circulating omentin levels. This suggests that reduced omentin may contribute to the development of metabolic disorders. Conversely, higher omentin levels appear to be associated with better glycaemic control.

Obesity

Individuals with obesity tend to have lower blood omentin concentrations. Notably, omentin levels rise following weight loss, indicating a close relationship between body weight and omentin production.

Cardiovascular Disease

Low omentin levels have been linked to an increased risk of atherosclerosis (hardening of the arteries) and other cardiovascular conditions. The vascular-protective properties of omentin may play a role in reducing this risk.

Polycystic Ovary Syndrome (PCOS)

Women with PCOS, a common hormonal disorder often associated with insulin resistance, have also been found to have reduced omentin levels. Omentin may represent a connecting factor between PCOS and metabolic dysfunction.

Other Conditions

Growing evidence suggests that altered omentin levels may also be relevant in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, as well as in certain types of cancer. Research in these areas is ongoing.

How is Omentin Measured?

Omentin levels in the blood can be measured using specialised laboratory tests, most commonly the ELISA (Enzyme-linked Immunosorbent Assay). This measurement is currently primarily used in research settings and is not part of routine clinical diagnostics. Normal blood levels typically range from approximately 100 to 300 ng/ml, though reference ranges may vary depending on the laboratory and method used.

Factors That Influence Omentin Levels

Several lifestyle factors can affect circulating omentin levels:

Body weight: Weight loss is associated with an increase in omentin levels.
Diet: A Mediterranean or high-fibre diet may positively influence omentin concentrations.
Physical activity: Regular exercise has been associated with higher omentin levels.
Medications: Certain diabetes medications, including metformin and thiazolidinediones, have been shown to increase omentin levels.

Therapeutic Potential

Due to its broad protective effects, omentin is being investigated as a potential therapeutic target for the treatment of metabolic and cardiovascular diseases. However, no approved medications specifically designed to raise omentin levels currently exist. Ongoing research aims to better understand the precise mechanisms of omentin action in order to develop new treatment strategies.

References

Yang, R. Z. et al. (2006): Identification of omentin as a novel depot-specific adipokine in human adipose tissue. Biochemical and Biophysical Research Communications, 344(4), 1325–1333.
Schaffler, A. & Neumeier, M. (2010): Omentin in metabolic and inflammatory disease. Clinical Endocrinology.
Pan, H. Y. et al. (2019): Omentin-1 and metabolic syndrome: A systematic review and meta-analysis. Clinical Endocrinology, 90(6), 744–754.

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