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Spinal Epidural Hematoma – Causes & Treatment

A spinal epidural hematoma is a rare but serious accumulation of blood in the epidural space of the spine that can compress the spinal cord and lead to paralysis.

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Things worth knowing about "Spinal Epidural Hematoma"

A spinal epidural hematoma is a rare but serious accumulation of blood in the epidural space of the spine that can compress the spinal cord and lead to paralysis.

What is a Spinal Epidural Hematoma?

A spinal epidural hematoma (SEH or SSEH) is an abnormal collection of blood within the epidural space of the spine – the area between the bony spinal canal and the outer membrane of the spinal cord (the dura mater). This blood collection can compress the spinal cord or nerve roots and represents a neurosurgical emergency requiring rapid diagnosis and treatment.

Causes

Spinal epidural hematomas may occur spontaneously or be triggered by various factors:

Anticoagulant therapy: The most common cause; blood thinners such as heparin, warfarin, or direct oral anticoagulants significantly increase the risk of bleeding.
Spinal procedures: Such as epidural anesthesia, lumbar puncture, or spinal surgery.
Trauma: Falls, accidents, or direct injuries to the spine.
Coagulation disorders: Congenital or acquired conditions such as hemophilia or thrombocytopenia.
Vascular malformations: Arteriovenous malformations in the spinal region.
Idiopathic: In some cases, no clear cause is identified (spontaneous spinal epidural hematoma).

Symptoms

Symptoms often develop suddenly and progress rapidly. Typical signs include:

Acute, severe back or neck pain: Often the first and most prominent symptom, frequently described as sharp or tearing.
Motor weakness: Reduced strength or paralysis of the legs (thoracic or lumbar hematoma) or arms (cervical hematoma).
Sensory disturbances: Numbness, tingling, or loss of sensation below the level of bleeding.
Bladder and bowel dysfunction: Urinary retention, incontinence, or constipation as signs of cauda equina involvement.
Paraplegia or tetraplegia: In severe cases, complete paralysis below the level of the lesion.

Diagnosis

Diagnosing a spinal epidural hematoma requires prompt action. The following examinations are used:

MRI of the spine: The preferred method – reliably shows the location, extent, and degree of spinal cord compression without radiation.
CT of the spine: Rapidly available, especially in emergencies or when MRI is not feasible; useful for assessing bony structures.
Neurological examination: Assessment of motor function, sensation, and reflexes to determine the severity of impairment.
Laboratory tests: Complete blood count and coagulation parameters (INR, aPTT) to identify risk factors.

Treatment

A spinal epidural hematoma is a medical emergency. Treatment depends on the clinical presentation and the time elapsed since symptom onset.

Surgical Treatment

Surgical decompression (laminectomy with hematoma evacuation) is the standard treatment for patients with neurological deficits. It should ideally be performed within 12 to 24 hours of symptom onset, as neurological outcomes are strongly linked to the timing of surgery. The earlier the intervention, the better the chances of neurological recovery.

Conservative Treatment

In selected cases – such as minimal or improving symptoms, high surgical risk, or complete spontaneous resolution – a conservative approach with close neurological monitoring and reversal of anticoagulation may be considered.

Supportive Measures

Immediate reversal or discontinuation of anticoagulant medications
Intensive care monitoring
Early rehabilitation following surgical intervention

Prognosis

Prognosis depends critically on the time to treatment and the degree of neurological deficit present before the intervention. Patients with mild deficits and early surgery have a good chance of full recovery. Prolonged complete paralysis before surgery may result in permanent neurological damage. Therefore, immediate medical attention is essential when a spinal epidural hematoma is suspected.

References

Kreppel D, Antoniadis G, Seeling W. Spinal hematoma: a literature survey with meta-analysis of 613 patients. Neurosurg Rev. 2003;26(1):1-49.
Greenberg MS. Handbook of Neurosurgery. 9th ed. Thieme Medical Publishers; 2019.
Vandermeulen EP, Van Aken H, Vermylen J. Anticoagulants and spinal-epidural anesthesia. Anesth Analg. 1994;79(6):1165-1177.

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