ag Your fresh start in 2026: A cure for many resolutions – now with a 15% early bird discount! ag ag Your fresh start in 2026: A cure for many resolutions – now with a 15% early bird discount! ag X
Go to homepage
€0.00
artgerecht Home Home

Fusion protein - biotechnological active principle in therapy and diagnostics

Fusion proteins combine two functional proteins in one molecule and are used in cancer therapy, immunomodulation and diagnostics. Find out more about the structure, benefits and clinical applications.

Interested in regular tips & information about health? Interested in regular tips & information about health?
Lexicon: F
Fusion protein
0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Start Page | Table of Contents
Lexicon Navigation
0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Start Page Table of Contents

Wissenswertes über "Fusion protein"

Fusion proteins combine two functional proteins in one molecule and are used in cancer therapy, immunomodulation and diagnostics. Find out more about the structure, benefits and clinical applications.

fusion protein is an artificially produced protein molecule that consists of two or more genetically linked protein components that consists of two or more genetically linked protein components. These proteins usually retain their individual functions, but complement each other to form a new biological mechanism of action that can be used therapeutically or diagnostically. Fusion proteins are created using recombinant DNA technology and are used in biomedicine, oncology, immunotherapy, vaccine development and cell research.

.

fusion of two gene sequences, each of which codes for functional proteins or peptide fragments. These are introduced into suitable expression systems (e.g. bacteria, yeasts or mammalian cells) and expressed. The resulting proteins are often connected to linkers, which ensure structural flexibility between the protein domains.

  • Target structure (e.g. antibody fragment, ligand, peptide sequence)

  • Active domain (e.g. enzyme, cytokine, toxin, coagulation factor)

    • 1. Cancer therapy:
    A well-known example is the fusion protein tTF-NGR, which is used in the TRABTRAP study. It consists of:

    • tTF (truncated tissue factor): activates blood clotting

    • NGR peptide: binds specifically to CD13 on tumour-associated vessels
      → Goal: close tumour vasculature and starve cancer cells

    2. immunomodulation & autoimmune diseases:

    • Etanercept (Enbrel®): fusion protein from TNF receptor and Fc part of IgG1
      → Inhibits tumour necrosis factor-α in rheumatoid arthritis and psoriasis

    3rd vaccine development & diagnostics:

    • fusion proteins with fluorescent markers or carrier proteins, e.g. in COVID-19 research

    • increase the immune response

    4. gene therapy & cell biology:

    • visualisation of protein transport and cell compartmentation

  • Targeted effect with minimal damage to healthy cells

  • Combination of therapeutic and diagnostic properties

  • Stability and half-life can be improved through targeted structural designs

  • key tool of modern biotechnology and open up new avenues in personalised medicine and tumour therapy.

    Literature references:

    • Journal of Immunology.

    • ""tTF-NGR - A targeted fusion protein in vascular tumour therapy."" Clinical Cancer Research.

    • Biotechnology Journal.

    • Die neusten Einträge

    3 Posts in this encyclopedia category

    PHGG

    PHGG steht für Partially Hydrolyzed Guar Gum, ein teilweise hydrolysiertes Guarkernmehl, das als löslicher Ballaststoff in der Ernährungstherapie eingesetzt wird.
    Read more

    Hematuria

    Hämaturie bezeichnet das Vorhandensein von Blut im Urin, das mit bloßem Auge oder durch eine mikroskopische Untersuchung sichtbar gemacht wird.
    Read more

    German Association of Occupational Therapy

    Der DVE (Deutsche Verband der Ergotherapie e.V.) ist die zentrale Fach- und Interessenvertretung der Ergotherapeuten in Deutschland.
    Read more

    Die meistgelesenen Einträge

    3 Posts in this encyclopedia category

    Magnesiumcarbonat

    Magnesiumcarbonat ist eine anorganische Magnesiumverbindung mit säure-neutralisierender (antazidischer)   Wirkung. Erfahre mehr über Vorteile, Einsatzgebiete und Unterschiede zu besser resorbierbaren Magnesiumformen.
    Read more

    Cologne list

    The Cologne List ® is an important initiative in competitive sports that offers athletes guidance in the selection of nutritional supplements.
    Read more

    Calorie content

    The choice of food influences our energy intake. The calorie content varies greatly - some provide little energy, others a lot.
    Read more

    Verwandte Suchbegriffe: Fusion protein + fusion protein

    COOKIE SETTINGS

    We use cookies to make it easier for you to use the website and to improve our products. You decide which cookies you accept or reject. You can change your decision at any time in the website settings.