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Angiogenesis - formation of new blood vessels: importance for healing, tumour growth and therapy

Angiogenesis is the formation of new blood vessels - central to healing, but also to tumour growth. Find out more about physiological functions, pathological processes and therapeutic approaches.

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Angiogenesis is the formation of new blood vessels - central to healing, but also to tumour growth. Find out more about physiological functions, pathological processes and therapeutic approaches.

Angiogenesis refers to the new formation of blood vessels from existing vessels. This physiological process is essential for wound healing, tissue supply, organ development and reproduction. At the same time, angiogenesis also plays a central role in pathological processes, in particular in tumour growth, chronic inflammation and eye diseases.

pro- and anti-angiogenic factors. It is activated by:

  • Wound healing

  • Menstrual cycle

  • Embryonic development

  • Adaptation to oxygen deficiency (hypoxia)

  • VEGF (vascular endothelial growth factor)

  • FGF (fibroblast growth factor)

  • PDGF, TGF-β and angiopoietin

    • endothelial cells to proliferate, migrate and sprout vessels.

    dysregulated or excessive angiogenesis is associated with numerous diseases:

    • Cancer: Tumours stimulate angiogenesis to supply themselves with nutrients (tumour angiogenesis)

    • Rheumatoid arthritis: Inflammatory changes in the joints form new blood vessels

    • Diabetic retinopathy & macular degeneration: pathological vascularisation in the eye

    • Psoriasis: vascular growth in inflamed skin tissue

    goal and a tool of modern medicine:

    1. angiogenesis inhibition (anti-angiogenesis):

    • Stop tumour growth, e.g. with VEGF inhibitors

    • 2. promotion of angiogenesis (pro-angiogenesis):

      • Healing of circulatory disorders (e.g. chronic wounds or heart attacks)

      • TRAPTRAP study is taking a different approach: The protein tTF-NGR is used to specifically interrupt the tumour supply by targeting the tTF-NGR.strong data-start=""2461"" data-end=""2529"">selectively blocking and occluding tumour-associated angiogenesis - a new therapeutic approach that exploits angiogenesis to specifically starve tumours.

        Literature references:

        • Nature Reviews Drug Discovery.

        • Nature.

        • Nature Reviews Cancer.

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    Verwandte Suchbegriffe: Angiogenesis

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